厦门大学 细胞生物学 叶军 视频教程
课程大纲
Introduction of Molecular cell biology
The objectives and development of cell biology
Microscope and Cell theory
Major events in cell biology
Cell theory-test
Culturing and visualizing cells
Growing Cells in Culture
Monoclonal antibodies
Fluorescence Microscopy
Flow cytometry
Spinning Disk Confocal Microscopy
FRAP and FRET
RNA interference
Culturing and visualizing cells-test
Biomembrane Structure
The structrures of the plasmic membrane
The lipid bilayer: Composition and structural organization
Forms of lipid molecules exist in water
Lipids Movement in biomembrane
Structure of Membrane Proteins
Synthesis of Phospholipids and Intracellular Movement
Biomembrane Structure-test
Glyphosate and cancer
Glyphosate (草甘膦) and cancer
Transmembrane transport of Ions and small molecules
Overview of transmembrane transport
Facilitated Transport of Glucose and Water
ATP –powered pumps
Na+/k+ pump
Ca2+ pump
K+ channel and the Resting membrane potencial
Cotransport by Symporters and Antiporters
Transcellular transport
Transmembrane transport of Ions and small molecules
Cellular Energetics
Overview of aerobic oxidation
Structure of Mitochondria
Mitochondrial Oxidation of Fatty Acids Generates ATP
The Electron Carriers and Electron Transport Chain
The Electron Transport and Generation of the Proton-Motive Force
Chemiosmotic theory and Endosymbiont hypothesis
Harnessing the Proton-Motive Force to synthesize ATP
Electron Transport and Reactive Oxygen Species (ROS)
Cellular Energetics
Moving Proteins into Membranes and Organelles
Targeting Proteins to and Across the ER Membrane
Insertion of single-pass Proteins into the ER
Insertion of Multipass Proteins into the ER
Protein Glycosylation and Folding in the ER
Formation of disulfide bonds in the ER
Protein Quality Control in the ER
Targeting of Proteins to Mitochondria
Targeting of Peroxisomal Proteins
Moving Proteins into Membranes and Organelles
Vesicular traffic,secretion and endocytosis
Vesicular traffic,secretion and endocytosis
Molecular Mechanisms of Vesicle Budding and Fusion
Early Stages of the Secretory Pathway
Later Stages of the Secretory Pathway
Receptor-Mediated Endocytosis
Directing Membrane Proteins and Cytosolic Materials to the Lysosome
The structure and functions of Lysosomes
Signal transduction and G protein-coupled receptors
Brief Introduction of Cell Communication
Signaling Molecules and Receptors
G Proteins and G Protein-coupled Receptors (GPCR)
GPCR Mediated Signaling pathways
Signal transduction
Signaling pathways that control gene activity
Outlines of Signaling pathways that control gene activity
Phosphoinositide Signaling Pathways
TGF-b Receptors and TGFb Signaling Pathways
Signaling Pathways controlled by Ubiquitination
The Ras/MAPK and JAK/STAT signaling pathway
Signaling pathways that control gene activity
Cell organization and movement I: Microfilaments
Actin Filaments
Dynamic Assembly of Actin Filaments
Actin-Based Cellular Structures
Myosins and Myosin-Powered Movements
Cell organization and movement I: Microfilament
Cell organization and movement II: Microtubules and intermediate filament
第一单元 Microtubule Structure and Organization
第二单元 Microtubule Dynamics
第三单元 Regulation of Microtubule Structure and Dynamics
第四单元 Kinesins & Dyneins: Microtubule-Based Motor Proteins
第五单元 Cilia & Flagella: Microtubule-Based Surface Structures
第六单元 Mitotic Spindle
第七单元 Intermediate Filaments
第八单元 Coordination and Cooperation Between Cytoskeletal Elements
Cell organization and movement II: Microtubules and intermediate filamen
Nucleus, chromatin and chromosomes
第一单元 Unit 1, Nuclear Envelope (NE), Nuclear Pore Complex (NPC) & Nuclear Transport
第二单元 Unit 2, Structural Organization of Eukaryotic Chromosomes
第三单元 Unit 3, Morphology and Functional Elements of Eukaryotic Chromosomes
第四单元 Unit 4, Nucleolus
Nucleus, chromatin and chromosomes 单元测验
The Eukaryotic Cell Cycle
第一单元 Unit 1, Overview of the Cell Cycle and Its Control
第二单元 Unit 2, Model Organisms and Methods to Study the Cell Cycle
第三单元 Unit 3, CDK and Its Discovery
第四单元 Unit 4, Regulation of CDK Activity
第五单元 Unit 5, Commitment to the Cell Cycle and DNA Replication
第六单元 Unit 6, Entry into Mitosis and Completion of Mitosis
第七单元 Unit 7, Surveillance Mechanisms in Cell Cycle Regulation
第八单元 Unit 8, Meiosis: A Special Type of Cell Division
The Eukaryotic Cell Cycle-test
Integrating cells into tissues
An Overview on Cell-Cell and Cell-Matrix Adhesion
Type of Cell Junctions and Anchoring Junctions
Tight junctions and Gap junctions
ECMs of The Basal Lamina
ECMs of Connective tissue
Ch20 Test -single answer choice
Stem cells, cell asymmetry and cell death
Early metazoan developmnt and embryonic stem cells
Stem Cells and Niches in Multicellular Organisms
Mechanisms of cell polarity and asymmetric cell division
Cell death and its regulation
Ch21 Test- single answer Choice
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